Future Trunks uses this attack in his Super Saiyan form during his battle against Future Android 17 and Future Android 18 in the TV special Dragon Ball Z: The History of Trunks. After being blasted away by Future Android 17 and 18, Future Trunks emerges from the explosion, and attacks and knocks the two Androids away. Future Trunks then flies up into the air and fires the Buster Cannon down at Future Android 17 and 18, creating a huge explosion. Future Trunks believes he has won, but as the smoke clears, Future Android 17 and 18 appear unaffected by the attack, much to the Future Trunks' shock.
Present Trunks uses the Buster Cannon Future Trunks uses the attack again in an attempt to destroy Android 17 and Android 18 before they activate Android 16 in the present timeline. Future Trunks had experienced a long, dreadful life under the Androids' power in his future world, and he does not want to witness it in another timeline either, especially with the help of another, unknown android. Trunks goes crazy and fires the big, yellow energy wave at the Red Ribbon Androids, completely ignoring the Z Fighters standing right by him, leaving a mushroom cloud in its wake and destroying Dr. Gero's Lab completely. However, the androids were fast enough to escape the blast at the last second, carrying Android 16 in his "coffin". In Dragon Ball GT, Present Trunks uses the Buster Cannon several times on planet Pital, both against Baby and controlled by Baby.